Study: Proton therapy effectively targets breast cancer with curative radiation doses while nearly eliminating radiation to the heart

By Theresa Edwards Makrush

Proton vs photon dose_0.jpgResearchers at UF Health Proton Therapy Institute have reported that for women with breast cancer, proton therapy can significantly reduce and in some cases nearly eliminate the dose to the heart, even when the lymph nodes overlying the heart need to be treated. In addition, proton therapy may reduce the exposure of the lung by 30 percent to 50 percent and provide better dose coverage to the lymph node regions as compared with conventional radiation.

These early results are from a pilot study conducted at the UF Health Proton Therapy Institute and published last month. Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared with Photons. (May 2016, International Journal of Radiation Oncology Biology Physics)

Eighteen women, nine with left-sided breast cancer and nine with right-sided breast cancer, were enrolled in the prospective study and followed for 20 months by lead researcher Julie A. Bradley, M.D., a radiation oncologist at the UF Health Proton Therapy Institute and faculty member at the University of Florida College of Medicine’s Department of Radiation Oncology.

In every patient, the proton plan was superior to the conventional plan in reducing the amount of radiation to the heart and lungs.

To learn more, click to read an interview with Dr. Bradley about the study.

About This Newsletter

The Precision Newsletter is an electronic-only publication that is distributed by email. Each issue is sent monthly to patients, alumni patients and friends of the University of Florida Health Proton Therapy Institute. As the official newsletter of the Institute, the content is compiled and prepared by our communications representative and approved by the editor Stuart Klein, executive director of UF Health Proton Therapy Institute. Special bulletin newsletters may occasionally be prepared when timely topics and new developments in proton therapy occur. If you would like to send a Letter to the Editor, please click here.


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